A new generation
of skin care ingredients has arrived
See the results
The extension of life expectancy, growth in female employment rates and late retirement have played an important role in the impressive growth of the cosmetic industry over the last decades worldwide.
Over the same period of time, pharma and chemical corporations have embarked on a race to find the most powerful and effective active ingredients, mostly derived from natural (plant) or synthetic origin.
Such new compounds have also become the source of inspiration for the newest creations of master formulators which have designed some of the most effective and popular skin care products in the world.
Peptides, plant extracts and probiotics have been the protagonists over the last few years, but the trend is changing.
RxGenesys technologies are inspired by the way the human body naturally behaves during its peak performance periods. Understanding how cells behave during such periods hold the key to maintain or improve their function over larger periods of time.
Two elements are critical in the development of a complete anti-aging solution
Revitalization and maintenance of the skin’s natural cellular processes
Protection of the cellular niche against the aggression of external elements
inspired by the natural function of the human body
A young looking and revitalized skin is the direct result of the healthy and natural function of its cells, specially the most common kind of cell in connective tissue called Fibroblasts which synthesize Collagen, Elastin, Fibronectin and Laminin in the skin, key components for its proper structural support.
Aiming for a substance capable of stimulating the fibroblasts in the skin, scientists have devoted decades to the study of Growth Factors and the process of producing them using adult stem cells.
Growth Factors are a naturally occurring substance in the human body which has been proven to stimulate fibroblasts, resulting in the promotion of cellular proliferation, healing, and cellular differentiation, making it an extremely desirable ingredient to add to skin care compounds.
Unfortunately its human origin has intrinsic disadvantages such as lack of stability when mixed, short active lifespan and immunoreactivity. Recent technology advances accessible to RxGenesys have made available an improved and much more stable substitute, RxGen Prime1 a Biomimetic Growth Factor, which have the same fibroblast stimulation effect (Collagen VII, Laminin-5 and Fibronectin production) without the intrinsic disadvantages and side effects of its human version
The latest innovation in stem cell technology for skin care was inspired on the Nobel Prize Award winning research in 2006 and 2012. Based on the utilization of microRNA, iPS (induced Pluripotent Stem Cell) Technology was discovered during advanced research for cancer treatments. Our patented iPS Technology and the RxGen Prime 3 - iPS Cell Extract included in our Skin Care solution have shown remarkable properties in the treatment of aging skin and wound healing by moderating gene transcription and protein expression.
Induced pluripotent stem cell - Summary
Induced pluripotent stem cells (also known as iPS cells or iPSCs) are a type of pluripotent stem cell that can be generated directly from adult cells. The iPSC technology was pioneered by Shinya Yamanaka from Kyoto University, Japan, who showed in 2006 that the introduction of four specific genes could convert adult cells into pluripotent stem cells. As a result he was awarded the 2012 Nobel Prize along with Sir John Gurdon "for the discovery that mature cells can be reprogrammed to become pluripotent.”
Induced pluripotent stem cell - No ethical controversy
The most well-known type of pluripotent stem cell is the embryonic stem cell. However, since the generation of embryonic stem cells involves destruction (or at least manipulation) of the pre-implantation stage embryo, there has been much controversy surrounding their use. Furthermore, because embryonic stem cells can only be derived from embryos, it hasn't been feasible to create patient-matched embryonic stem cell lines so far.
Since iPSs can be derived directly from adult tissues, the need for embryos can be bypassed. Our iPS extract, therefore can be safely used in wound and skin care products without causing immunologic reactions.
Recent studies estimate that sun effects can be responsible for up to 90% of premature skin aging. Protecting the skin against photoaging takes more than reducing the effects of Ultraviolet rays (UV). It also involves shielding the skin against the harmful effects of Infrared rays (IR) and the heat they generate.
UV and IR penetrate the skin at different depths, but both have degrading effects on the elastic fibers of the dermis. Such degrading effect is the consequence of the presence of Cathepsin G, an enzyme highly present on photoaged skin that promotes the synthesis of MMPs, which are responsible for fiber degradation.
RxGen Prime2 - Enzyme Inhibiting Botanical Active Compound included in the RxGenesys Skin Care Solution inhibits the activity of Cathepsin G, protecting Tropoelastin and Fibrilin-1, main components of the elastic fibers, which in turn help promote skin firmness and elasticity.